Structure of Adenonvirus VAI RNA
Activation of PKR by ss-dsRNAs
Dimer interface of SecA
A homo-FRET assay for PKR dimerization
RNA structure
Global Fit U30 binding to PKR
Chris Mayo's Thesis Defense
Complex RNAs Regulate PKR
Human powered analytical ultracentrifuge
News
- New publication on RIG-I like receptorsWe have a new paper coming out in Protein Science: Zerbe, C.M., Mouser, D.J. and Cole, J.L. (2019) Oligomerization of RIG-I and MDA5 2CARD Domains. Protein. Sci., in press.
- Cassie Zerbe, Ph.D.Cassie Zerbe did a great thesis defense presentation on October 8 and is now Dr. Cassie Zerbe.
- Emphutos TherapeuticsJim has formed a company, Emphutos Therapeutics, to develop novel antiviral agents that target the host immunity pathway.
Recent Publications
Mayo, C.B., Erlandsen, H., Mouser, D.J., Feinstein, A.G., Robinson, V.L., May, E.R., Cole, J.L. (2019) Structural basis of protein kinase autophosphorylation. Biochemistry, in press.
Maniaci, B., Lipper, C. H., Anipindi, D. L., Erlandsen, H., Cole, J. L., Stec, B., Huxford, T. and Love, J.J.(2019). Design of High-Affinity Metal-Controlled Protein Dimers. Biochemistry, 58, 2199–2207.
Pindrus, M.A., Cole, J.L., Kaur, J., Shire, S.J., Yadav, S. and Kalonia, D.S. (2017) Effect of aggregation on the hydrodynamic properties of bovine serum albumin. Pharm. Res. 34. 2250–2259.
Mayo, C.B. and Cole, J.L. (2017) Interaction of PKR with single-stranded RNA. Sci Rep. 7, 3335.
Mayo, C.B., Wong, C.J., Lopez P.E., Lary, J.W. and Cole, J.L. (2016) Activation of PKR by short stem-loop RNAs containing single-stranded arms. RNA 22, 1065-1075. doi:10.1261/rna.053348.115.
Contact
| Phone: | (860) 486-4333 |
|---|---|
| E-mail: | james.cole@uconn.edu |
| Address: | 91 North Eagleville Road Storrs, Connecticut 06269-3125 |